研究業績

2023

Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome
Zhang Z, Shibata T, Fujimura A, Kitaura J, Miyake K, Ohto U, Shimizu T.
Nature 622, 188-194

Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation
Ueno T, Tsuchiya Y, Watanabe Y, Otsuka T, Saito H, Nagatoishi S, Tsumoto K, Kojima H, Okabe T, Shimizu T, Urano Y.
Sci. Rep. 13, 16456

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders
Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, Tojo A, Ohtsuki M, Ohto U, Shimizu T, Ozawa M, Yoshida N, Isobe T, Latz E, Mukai K, Taguchi T, Hemmi H, Akira S, Miyake K.
J. Exp. Med.​ 220, e20230054

A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus
Ishizaka ST, Hawkins L, Chen Q, Tago F, Yagi T, Sakaniwa K, Zhang Z, Shimizu T, Shirato M.
Eur. J. Pharmacol. 957, 175962

TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction
Sakaniwa K, Fujimura A, Shibata T, Shigematsu H, Ekimoto T, Yamamoto M, Ikeguchi M, Miyake K, Ohto U, Shimizu T.
Nature commun. 14, 164

Structural insight into the activation of an Arabidopsis organellar C-to-U RNA editing enzyme by active site complementation 
Sachiko Toma-Fukai, Yuto Sawada, Ayako Maeda, Hikaru Shimizu,Toshiharu Shikanai, Mizuki Takenaka and Toshiyuki Shimizu​
The Plant Cell 35, 1888-1900
 


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東京大学
東京大学大学院 薬学系研究科・薬学部
PF-UA タンパク質結晶構造解析ユーザーグループ