研究業績

2013

A nonclassical vitamin D receptor pathway suppresses renal fibrosis. (2013)
Ito, I., Waku, T., Aoki, M. Abe, R., Nagai, Y., Watanabe, T., Nakajima,Y., Ohkido, I., Yokoyama, K., Miyachi, H., Shimizu, T., Murayama, A., Kishimoto , H., Nagasawa, K., Yanagisawa, J.
J. Clin. Invest. 123, 4579-4594

Impaired α-TTP-PIPs Interaction Underlies Familial Vitamin E Deficiency. (2013)
Kono N.*, Ohto U.*, Hiramatsu T., Urabe M., Uchida Y., Satow Y., and Arai H. 
Science 340, 1106-1110 (* equally contributed)

TLR4-MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide. (2013)
Kondo Y., Ikeda K., Tokuda N., Nishitani C., Ohto U., Akashi-Takamura S., Ito Y.,Uchikawa M., Kuroki Y., Taguchi R., Miyake K., Zhang Q., Furukawa K., and Furukawa K.
Proc Natl Acad Sci U S A. 110, 4714-4719.

Structural reorganization of the Toll-like receptor8 dimer induced by agonistic ligands (2013)
Tanji H.*, Ohto U.*, Shibata T., Miyake K., and Shimizu T. 
Science 339, 1426-1429 (* equally contributed)

Structural basis for vitamin D receptor agonism by novel nonsecosteroidal ligands (2013)
Asano L., Ito I., Kuwabara N., Waku T., Yanagisawa J., Miyachi H. and Shimizu T.
FEBS letters 587, 957-963

Characterisation of an intrinsicallly disordered potein complex of Swi5-Sfr1 by ion mobility mass spectrometry and small-angle X-ray scattering (2013)
Saikusa K., Kuwabara N., Kokabu Y., Inoue Y., Sato M., Iwasaki H., Shimizu T., Ikeguchi M. and Akashi S.
Analyst 138, 1441-1449

Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A (2013)
Yamakawa N.*, Ohto U.*, Akashi-Takamura S., Takahashi K., Saitoh S., Tanimura N., Suganami T., Ogawa Y., Shibata T., Shimizu T., and Miyake K. 
Int. Immunol. 25, 45-52 (* equally contributed)

Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner
Deguchi, A., Tomita, T., Omori, T., Komatsu, A., Ohto, U., Takahashi, S.,Tanimura, N., Akashi-Takamura, S., Miyake, K., & Maru, Y.
J. Immunol.191,1856-1864

自然免疫系RNA受容外TLR8の結晶構造(2013)
丹治裕美、大戸梅治、清水敏之
結晶学会誌 55, 285-289

ライソゾーム病原因タンパク質β－ガラクトシターゼの構造基盤 (2013)
清水敏之
薬学雑誌 133, 509-517