研究業績

2015

DNase II-dependent DNA digestion is required for DNA sensing by TLR9
Chan M.P., Onji M., Fukui R., Kawane K., Shibata T., Saitoh S., Ohto U., Shimizu T., Barber G. and Miyake, K.
Nature com. 6, 5853

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases
Kanno A., Tanimura N., Ishizaki M., Ohko K., Motoi Y., Onji M., Fukui R., Shimozato T., Yamamoto K., Shibata T., Sano S., Sugahara-Tobinai A., Takai T., Ohto U., Shimizu T., Saitoh S. and Miyake K.
Nature com. 6, 6119

Toll-like receptor 8 senses degradation products of single-stranded RNA
Tanji H., Ohto U., Shibata T., Taoka M., Yamauchi Y., Isobe T., Miyake K., and Shimizu T.
Nature Struc. Mol. Biol. 22, 109-115

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9 
Ohto U., Shibata T., Tanji H., Ishida H., Krayukhina E., Uchiyama S., Miyake K. and Shimizu T.
Nature 520, 702-705

Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance.
Hishiki A, Hara K, Ikegaya Y, Yokoyama H, Shimizu T, Sato M, Hashimoto H.
J. Biol. Chem. 290, 13215-13223

Crystal structure of human Roquin-2 and its complex with constitutive decay
element RNA
Sakurai S., Ohto U. and Shimizu, T.
Acta Crystallogr. F71,1048-1054

The Imidazoquinoline Toll-like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes 
Ganapathi, L., Van Haren, S., Dowling, D.J., Bergelson, I., Shukla, N.M., Malladi, S.S., Balakrishna, R., Tanji, H., Ohto, U., Shimizu, T., David, S.A. and Levy, O.
PLoS One 10, e0134640

Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity.
Beesu M, Caruso G, Salyer A, Khetani K, Sil D, Weerasinghe M, Tanji H, Ohto U, Shimizu T, David SA.
J. Med. Chem. 58, 7833-7849

Toll様受容体8はRNAの分解物であるウリジンを認識する
丹治裕美、大戸梅治、清水敏之
臨床免疫・アレルギー科 64, 294-298

自然免疫における一本鎖RNA認識Toll様受容体８の構造基盤およびその医薬応用
清水敏之
医学のあゆみ 254, 541-545