研究業績

2016

Guanosine and its modified derivatives are endogenous ligands for TLR7.
Shibata T, Ohto U, Nomura S, Kibata K, Motoi Y, Zhang Y, Murakami Y, Fukui R, Ishimoto T, Sano S, Ito T, Shimizu T, Miyake K.
Int. Immunol. 28, 211-222

Analysis of the fine-tuning of cyanobacterial circadian phase by monochromatic light and long day conditions
Kobayashi T., Obana Y., Kuboi N., Kitayama Y., Hayashi S., Oka M., Wada N., Arita K., Shimizu T., Sato M., Kanaly R. and Kutsuna, S.
Plant Cell Phys. 57, 105-114

Novel helical assembly in arginine methyltransferase 8
Fuaki-Toma, S., Jun-Dal Kim, J.D., Park, K.E., Kuwabara, N. Shimizu, N., Krayukhina, E., Uchiyama, S., Fukamizu, A., Shimizu, T
J. Mol. Biol. 428, 1197-1208

Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8
Tanji, H., Ohto, U., Motoi, Y., Shibata, T., Miyake, K., Shimizu, T.
Proc. Natl. Acad. Sci., USA 113, 3012-3017

Structural aspects of nucleic acid-sensing Toll-like receptors 
Ohto, U. and Shimizu, T.
Biophysical Reviews 8, 33-43

Identification of a Human Toll-like Receptor (TLR) 8-specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles.
Beesu M, Caruso G, Salyer AC, Shukla NM, Khetani KK, Smith LJ, Fox LM, Tanji H, Ohto U, Shimizu T, David SA.
J. Med. Chem. 59, 3311-3330

NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner
Waku T, Nakajima Y, Yokoyama W, Nomura N, Kako K, Kobayashi A, Shimizu T, Fukamizu A
J. Cell. Sci. 129, 2382-2393

Crystal structure of NOD2 and its implications in human disease
Maekawa S, Ohto U, Shibata, T, Miyake, K, Shimizu T
Nature comm. 7, 11813

Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization
Ohto U, Ishida H, Krayukhina E, Uchiyama S, Inoue N, Shimizu T
Nature 534,566-569

Regulation mechanism of the vitamin D receptor by vitamin D lactam derivatives 
Asano L, Waku T, Rumi Abe R, Kuwabara N, Ito I, Yanagisawa J, Nagasawa K, Shimizu T
FEBS letters 590,3270-3279

Structural analysis reveals that Toll-like receptor 7 is a dual receptor for guanosine and single-stranded RNA
Zhang Z, Ohto U, Shibata T, Krayukhina E, Taoka M, Yamauchi Y, Tanji H, Isobe T, Uchiyama S, Miyake K and Shimizu T
Immunity 45,737-748

Emerging roles of the processing of nucleic acids and Toll-like receptors in innate immune responses to nucleic acids
Miyake K, Shibata T, Ohto U,, Shimizu T
J. Leukocyte Biol. , in press

精子と卵の結合の構造基盤の解明
大戸梅治、清水敏之
実験医学 34, 3036-3038

Toll-like receptorによる核酸の認識機構
大戸梅治、清水敏之
化学と生物 54,318-323

一本鎖核酸を認識するToll様受容体の構造解明およびその応用
清水敏之
薬学雑誌 136,173-178