研究業績

2017

Emerging roles of the processing of nucleic acids and Toll-like receptors in innate immune responses to nucleic acids
Miyake K, Shibata T, Ohto U, Shimizu T
J. Leukocyte Biol. 101,135-142

Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide
Hanaoka, K., Sasakura, K., Suwanai, Y., Toma-Fukai, S., Shimamoto, K., Takano, Y., Shibuya, N., Terai, T., Komatsu, T., Ueno, T., Ogasawara, Y., Tsuchiya, Y., Watanabe, Y., Kimura, H., Wang, C., Uchiyama, M., Kojima, H., Okabe, T., Urano, Y., Shimizu, T., and Nagano, T.
Sci. Rep. 7,40227

The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals
Sakurai S, Tomita T, Shimizu T and Ohto U
Acta Crystallogr. F73,130-137

Crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family
Murakami K, Nakano K, Shimizu T and Ohto U
Acta Crystallogr. F73,347-355

Structural insights into ligand recognition and regulation of nucleic acid-sensing Toll-like receptors
Shimizu T
Curr. Opi. Stuc. Biol. 47,52-59

Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding
Shimizu H, Toma-Fukai S, Saijo S, Shimizu N, Kontani K, Katada T, Shimizu T.
J. Biol. Chem. 292,13441-13448

Towards a structural understanding of nucleic acid-sensing Toll-like receptors in the innate immune system
Zhang Z, Ohto U, Shimizu T
FEBS letters 591,3167-3181

Conservation and Divergence of Ligand Recognition and Signal Transduction Mechanisms in Toll-Like Receptors
Ohto U
Chem. Pharm. Bull. 65,697-705

Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex.
Okamoto N, Mizote K, Honda H, Saeki A, Watanabe Y, Yamaguchi-Miyamoto T, Fukui R, Tanimura N, Motoi Y, Akashi-Takamura S, Kato T, Fujishita S, Kimura T, Ohto U, Shimizu T, Hirokawa T, Miyake K, Fukase K, Fujimoto Y, Nagai Y, Takatsu K.
J. Biol. Chem.292,15378-15394

Structural Basis of Autoinhibition and Activation of the DNA-targeting ADP-ribosyltransferase Pierisin-1.
Oda T, Hirabayashi H, Shikauchi G, Takamura R, Hiraga K, Minami H, Hashimoto H, Yamamoto M, Wakabayashi K, Shimizu T, Sato M.
J. Biol. Chem.292,15445-15455

The crystal structure of the AhRR/ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription
Sakurai S, Shimizu T, Ohto U
J. Biol. Chem.292,17609-17616 

Toll様受容体の分子機構を観る
清水敏之
医学のあゆみ 262,361-366

自然免疫の分子機構を観る－効率的にシグナルが伝達するしくみ－
大戸梅治
医学のあゆみ 262,388-394

受精にかかわる精子融合因子IZUMO1と卵子受容体JUNOの認識機構の解明
石田英子、大戸梅治、清水敏之
日本結晶学会誌 59,108-113

Toll様受容体TLR7はグアノシンおよび１本鎖RNAを認識する
清水敏之
臨床免疫・アレルギー科 68,387

初期免疫に関わる因子の構造基盤
清水敏之
感染 炎症 免疫 47, 35-45