研究業績

2021

Cryo-EM structures of Toll-like receptors in complex with UNC93B1
Hanako Ishida, Jinta Asami, Zhikuan Zhang, Tomohiro Nishizawa, Hideki Shigematsu, Umeharu Ohto and Toshiyuki Shimizu
Nature Struc Mol Biol. 28, 173-180

Structural and functional understanding of the toll-like receptors
Jinta Asami and Toshiyuki Shimizu
Protein Science 30, 761-772

Structural Diversity of Ubiquitin E3 Ligase 
Toma-Fukai S and Shimizu T
Molecules 26, 6682

Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists
Yang Y, Csakai A, Jiang S, Smith C, Tanji H, Huang J, Jones T, Sakaniwa K, Broadwell L, Shi C, Soti S, Ohto U, Fang Y, Shen S, Deng F, Shimizu T, Yin H.
Nat Commun.12, 4351

Improving particle quality in cryo-EM analysis using a PEGylation method
Zhang Z, Shigematsu H, Shimizu T, Ohto U
Structure ​29, 1192-1199

Toll様受容体をターゲットとする創薬
清水敏之
医学のあゆみ 278, 553-558